STUDY SYNOPSIS Study Design Number of subjects enrolled: Forty patients Two groups - 20 each Number of centers: One Study design: Single-blind, Switching Paradigm Extension: None specifically, although patients who do have a good clinical response to the treatment will probably be maintained on their medication at the discretion of their treating psychiatrist through normal hospital channels and, therefore, if desired, it would be possible to formally re-evaluate their condition at some later time.
Inpatient: Norristown State Hospital Sterigere Street Norristown, PA Study drug and dosing: Flexible: To be enrolled, all patients will have had an adequate treatment of risperidone defined as monotherapy of at least 6 mg total daily for three months or more prior to enrollment. Comparator s and dosing: Flexible: As stated above, all patients will have had an adequate treatment of risperidone prior to enrollment. Other treatments or programs: There will be no other study related treatment programs, although each patient whether inpatient or partial hospital patient will continue to receive their usual hospital or clinic care on a regular basis.
MedlinePlus related topics: Schizophrenia Smoking. Drug Information available for: Quetiapine. FDA Resources. Arms and Interventions. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.
Inclusion Criteria: Patients male or female between years of age must be diagnosed as having DSM-IV schizophrenia any subtype including schizoaffective disorder.
Patients must have shown a less-than-optimal clinical response to an adequate course of risperidone treatment and must be willing to agree to the possibility of receiving quetiapine as an alternative treatment for their mild to moderate psychotic symptoms. Patients must be active cigarette smokers. We define active cigarette smoking as patients who consume one pack of cigarettes or more per day.
Although there is no standard for defining active cigarette smokers, it has been our experience that the high rate of smoking activity on the hospital wards can have the effect of small elevations in cotinine levels even among "non-smoking" patients through second hand smoke.
Therefore, we want to insure that we enroll "heavy" smokers. Patients must be able to fully participate in the informed consent and HIPAA process, or have a legal guardian able to participate Exclusion Criteria: Patients who have had an adequate clinical response to risperidone and are considered by themselves or their treating psychiatrist to be clinically stable.
ECG abnormalities consistent with significant or acute cardiac disease. Active drug or alcohol addiction within the past 3-month period. Symptoms of significant physical illness in the 4-week period prior to enrollment, excluding mild upper respiratory or gastrointestinal disorders. Clinical laboratory findings that indicate the presence of a pathological condition in the judgment of the principal investigator. Having received any investigational drug in the 4 weeks preceding the study.
Pregnant or lactating patients are excluded. Pregnancy must be excluded by laboratory tests prior to beginning the study. Female patients judged to have potential for pregnancy sexually-active females who do not use an approved form of contraception will be excluded. At serious suicidal risk. Contacts and Locations. Your personal risks may depend on your condition, age, etc. Even though Seroquel does come with its possible dangers and risks, it is usually harmless if used responsibly and according to prescription.
If you experience any of the issues above while using Seroquel, talk to your doctor as soon as possible to discuss the best next steps. Seroquel can interact with certain other medications. It should not be combined with antiarrhythmic drugs, certain antibiotics, antipsychotic drugs, alcohol, or methadone. These drugs include benzodiazepines, muscle relaxants, certain pain medications, antihistamines, and sedatives.
You should always use Seroquel according to dosage. Your individual dosage will expend on your age, what condition you have, and other factors. If addiction occurs, inpatient treatment is likely the best solution. An inpatient program will begin with detoxing, which allows patients to experience the effects in withdrawal in a comfortable and healthy environment.
Tags: prescription drug use , prescription drugs , prescription medication , Seroquel. For the purposes of this model, relapse is defined as a return to marijuana use after a period of abstinence. Participants will begin taking capsules as outpatients so that the dose can be incremented prior to the inpatient phase.
While inpatient, participants will have the opportunity to self-administer placebo 0. Our laboratory model, which has distinguished the effects of a range of medications on marijuana withdrawal and relapse, will provide important information on the effect of quetiapine as a potential short-term pharmacotherapy to facilitate abstinence in the initial stages of marijuana treatment. Drug Information available for: Quetiapine. FDA Resources. Arms and Interventions.
Outcome Measures. Eligibility Criteria. Inclusion Criteria: Current marijuana use:average of 2 marijuana cigarettes per day at least 4 times per week for the past 4 weeks Able to perform study procedures years of age Women practicing an effective form of birth control condoms, diaphragm, birth control, pill, IUD Normal body weight Exclusion Criteria: Current, repeated illicit drug use other than marijuana Presence of significant medical illness e.
Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information. A human laboratory study investigating the effects of quetiapine on marijuana withdrawal and relapse in daily marijuana smokers.
Addict Biol. Epub Jun National Library of Medicine U.
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